Ayudhaya OP, Herabutya Y, Chanrachakul B, Ayuthaya NI, O-Prasertsawat P.
Department of Obstetrics and Gyneacology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama 6 Rd, Rachavithee, Bangkok 10400, Thailand.
Manosuthi W, Chottanapand S, Thongyen S, Chaovavanich A, Sungkanuparph S.
Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi and Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Kiertiburanakul S, Sungkanuparph S, Rattanasiri S, Manosuthi W, Vibhagool A, Thakkinstian A.
Division of lnfectious Diseases, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Cytochrome P450s or CYPs are heme proteins found in several organs but in high amount in both mammalian and human livers. The heme iron binds oxygen in the CYP active site, where oxidation of xenobiotics and endogenous compounds occurs. Electrons are supplied by the enzyme NADPH-cytochrome P450 oxidoreductase and its cofactor, NADPH. Metabolism of a substrate by a CYP consumes one molecule of O2 and produces on oxidized substrate and a molecule of water (Fig. 1).