A comparison of the efficacy of sublingual and oral misoprostol 400 microgram in the management of early pregnancy failure: a randomized controlled trial.

Ayudhaya OP, Herabutya Y, Chanrachakul B, Ayuthaya NI, O-Prasertsawat P.
Department of Obstetrics and Gyneacology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama 6 Rd, Rachavithee, Bangkok 10400, Thailand.

Survival rate and risk factors of mortality among HIV/tuberculosis-coinfected patients with and without antiretroviral therapy.

Manosuthi W, Chottanapand S, Thongyen S, Chaovavanich A, Sungkanuparph S.
Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi and Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Virological and immunological responses of efavirenz-based HAART regimen initiated in HIV-infected patients at CD4 < 100 versus CD4 > or = 100 cells/mm3.

Kiertiburanakul S, Sungkanuparph S, Rattanasiri S, Manosuthi W, Vibhagool A, Thakkinstian A.
Division of lnfectious Diseases, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Significance of muscularis mucosae in metastasis involvement of urinary bladder transitional cell carcinoma.

Chaimuangraj S, Dissaranan C, Leenanupunth C, Prathombutr P, Chalermsanyakorn P.
Division of Urology, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Initial experience and result of a Swedish adjustable gastric banding by laparoscopic approach in Thai cohorts.

Angkoolpakdeekul T, Samlitpradit P, Warodomwichit D, Roongpisuthipong C, Pongchailert P, Komindr S.

Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

A risk score for predicting incident diabetes in the Thai population.

Aekplakorn W, Bunnag P, Woodward M, Sritara P, Cheepudomwit S, Yamwong S, Yipintsoi T, Rajatanavin R. Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Suicide in Thailand during the period 1998-2003.

Lotrakul M.

Department of Psychiatry, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Transvaginal Doppler sonography: is there a role for this modality in the evaluation of women with postmenopausal bleeding?

Wilailak S, Jirapinyo M, Theppisai U.

Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Bangkok 10400, Thailand.

CYTOCHROME P450s

Cytochrome P450s or CYPs are heme proteins found in several organs but in high amount in both mammalian and human livers. The heme iron binds oxygen in the CYP active site, where oxidation of xenobiotics and endogenous compounds occurs. Electrons are supplied by the enzyme NADPH-cytochrome P450 oxidoreductase and its cofactor, NADPH. Metabolism of a substrate by a CYP consumes one molecule of O2 and produces on oxidized substrate and a molecule of water (Fig. 1).